ea0044oc4.4 | Adrenal and Steroids | SFEBES2016
Pazderska Agnieszka
, Oftedal Bergithe
, Napier Catherine
, Ainsworth Holly
, Husebye Eystein
, Cordell Heather
, Pearce Simon
, Mitchell Anna
Background: Autoimmune Addison disease (AAD) is a rare but highly heritable endocrinopathy. The BACH2 protein plays a crucial role in T lymphocyte maturation, and in particular in regulatory T cell formation, and allelic variation in its gene has been associated with autoimmune conditions such as type 1 diabetes, autoimmune thyroid disease and vitiligo. Its role in susceptibility to autoimmune Addisons disease (AAD) has not been investigated.Aim: T...